TheranosticTrials.org

Clinical Trial · NCT06878664

Randomized Interval Assessment Trial of Lu177-Dotatate in Slowly Progressive G1-2 Advanced Midgut Neuroendocrine Tumors

Overview

This is a randomized Phase II/late phase I de-escalation clinical trial with approved investigational medicinal products in new use condition, low intervention. Disease under study Patients with unresectable or metastatic, slowly progressive, well-differentiated (Grade1 and Grade2), somatostatin receptor-positive midgut neuroendocrine tumors (GEP-NETs). It is planned to randomize 166 patients with a histologically confirmed diagnosis of slowly progressive grade 1 or grade 2 advanced midgut neuroendocrine tumors (NETs) candidates to receive 177Lu-Dotatate targeted radioligand therapy (RLT). Patients are required to have SSTR+ disease, as evidenced on somatostatin receptor imaging. Patients will be randomized into two arms: 1. control arm: regimen 177Lu-Dotatate every 8 weeks (q8w) 2. experimental arm: regimen 177Lu-Dotatate every 16 weeks (q16w) Research hypothesis: Less intensive somatostatin-receptor (SST) targeted radioligand therapy (RLT) (7.4 GBq/cycle 177Lu-Dotatate every 16 weeks x 4 cycles) is associated with less severe hematological toxicities and may mitigate the risk to develop therapy-related myeloid neoplasms (t-MN) with similar antitumor efficacy in slowly growing gastrointestinal grade 1-2 NETs.

Sponsor

Unknown Organization

Phase

Phase 3

Contacts

Rocio Garcia Carbonero Garcia Carbonero, M.D., Ph.D. (STUDY_DIRECTOR)

Responsible person designated by the sponsor (CONTACT)

investigacion@mfar.net

+34 93 434 44 12

A responsible person designated by the sponsor (CONTACT)

investigacio@mfar.net

+34 93 434 44 12

Eric Baudin Baudin, M.D., Ph.D. (STUDY_DIRECTOR)

ClinicalTrials.gov

NCT06878664

Drug / Compound

DOTATATE

Isotope(s):
Target(s):
  • SSTR2
Ligand Class: Peptides
Chelator: DOTA

Eligibility

Inclusion

  • Life expectancy ≥ 12 months.
  • Serum albumin \<3.0 g/dL unless prothrombin time is within the normal range.
  • Serum bilirubin ≤ 3.0 × upper limit of normal (ULN) or ≤ 3 × ULN for subjects with Gilbert's disease
  • Adequate organ function (hematological, renal and liver) based upon meeting all of the following laboratory criteria:
  • In somatostatin receptor (SSTR) imaging all RECIST v1.1 evaluable target lesions and non-target lesions need to be SSTR positive (SSTR+) as defined by equal or above the liver uptake (this includes lesions of at least 10 mm in diameter in CT or MRI). If an FDG PET is performed (not mandatory), all FDG PET positive lesions should also be somatostatin receptor positive in SSRT imaging (see guidance Appendix 10).
  • Recovery to Grade ≤ 1 from any adverse event (AE) from prior treatment (excluding alopecia and/or asthenia).
  • Patients who have histologically confirmed diagnosis of unresectable, advanced or metastatic midgut NETs (originated in the jejunum-ileum or right colon) who are candidates to receive 177Lu-Dotatate targeted radioligand therapy (RLT) and SSA. Patients with a large SRI+ mesenteric mass with abdominal-dominant disease judged by the investigator to be a midgut NET will also be eligible.
  • Platelet count ≥ 75 × 109/L
  • Patients with health coverage (public or private), that includes coverage for patients enrolled in clinical trials, to both study treatments and determinations/procedures.
  • Patients may be treatment naïve (first-line) or have received prior systemic therapy except for any type of prior RLT (not restricted to 177Lu-Dotatate).
  • Subject agrees not to participate in another interventional study while on treatment in the present study.
  • Karnofsky performance status (KPS) scale ≥ 70%
  • Patient information and signing of the consent form, Institutional Review Board(IRB)/Independent Ethics Committee (IEC) approved, before any study-specific procedure. The patient must be able and willing to cooperate in monitoring study visits and procedures.
  • Ki-67 index ≤ 20%.
  • Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 × ULN or ≤ 5 xULN for subjects with liver metastases
  • Measurable disease according to RECIST v1.1 criteria (Appendix 3)
  • Neutrophil count (ANC) ≥ 2.000/mm3
  • Creatinine clearance (CrCl) ≥ 50 mL/min as estimated by the Cockroft-Gault formula or as measured by 24-hour urine collection (GFR can also be used instead of CrCl). Note: renal tract obstruction is not allowed.
  • Disease progression per RECIST v1.1 within 36 months prior to study entry,
  • Hemoglobin ≥ 8 g/dL

Exclusion

  • Prior radioligand therapy (RLT) (not restricted to 177Lu-Dotatate).
  • Patients who have a known active Hepatitis B (e.g., HBsAg reactive) or active hepatitis C (e.g., HCV RNA \[qualitative\] is detected). Patients who have a known active history of human immunodeficiency virus (HIV) infection (HIV 1 or 2).
  • Patients who have known hypersensitivity to lutetium-177 (177Lu), oxodotreotide, DOTA, somatostatin analogues, lysine, arginine, or any excipient/derivative of these agents
  • Serious non-malignant disease (e.g. psychiatric, infectious, autoimmune, cardiovascular or dementia), that may interfere with the objectives of the trial or with the safety or compliance of the patient, as judged by the investigator.
  • Male patients must agree not to donate sperm starting at screening and throughout the study period, and for at least 4 months after the final study drug administration.
  • Prior external beam radiation therapy (EBRT) to more than 25% of the bone marrow
  • Female patients must agree not to breastfeed or donate ovules starting at screening and throughout the study period, and for at least 7 months after the final study drug administration.
  • Other known malignancies unless cured or definitively treated with no evidence of recurrence for 3 years
  • Prior major surgery, systemic therapy, embolization or other locoregional treatments within 4 weeks of study entry
  • Patient under guardianship or curatorship or deprived of liberty by a judicial or administrative decision or patient unable to give consent.
  • Prior whole liver internal radiation therapy (SIRT)
  • For female patients of childbearing potential (defined as \< 2 years after last menstruation and not surgically sterile) and male patients who are not surgically sterile and have female partners of childbearing potential that do not agree to use a medically accepted and highly effective birth control method (i.e. those with a failure rate less than 1%; refer to Appendix 4) for the duration of the study treatment and for 7 months after the final dose of study treatment
  • Pregnancy or lactation. Men and women should not procreate during study treatment and until seven months after the final study drug administration.