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Clinical Trial · NCT05444686
Comparative Study of 99mTc-FAPI SPECT/CT and 68Ga-FAPI PET/CT
Overview
The purpose of this study is to compare the similarities and differences of 99mTc-FAPI quantitative SPECT/CT and 68Ga-FAPI PET/CT in the diagnosis and staging of gastrointestinal tumors, and clinical diagnosis and economic value of 99mTc-FAPI quantitative SPECT/CT for the gastrointestinal tumors.
Sponsor
Xijing Hospital
Phase
N/A
Contacts
Jing Wang, M.D, Ph.D (CONTACT)
wangjing@fmmu.edu.cn
86-29-84775449
ClinicalTrials.gov
NCT05444686Drug / Compound
FAPI
Isotope(s):
TECHNETIUM-99m
Radioisotope: Tc-99m
Theranostic Role: SPECT Imaging
T1/2 (Half-Life): 6 Hours
Decay Mode: GAMMA
Energy: 140 keV (89.1%)
Range: N/A
Decay Daughters: Tc99
Status: FDA Approval: First in 1980’s
Target(s):
- FAP
Ligand Class: Small Molecules
Chelator: HYNIC
FAPI
Isotope(s):
GALLIUM-68
Radioisotope: Ga-68
Theranostic Role: PET Imaging
T1/2 (Half-Life): 68 minutes
Decay Mode: POSITRON β+ (88.9%), GAMMA, ELECTRON CAPTURE (8.7%)
Energy: Beta: max 1.9 MeV Gamma 1.1 MeV, 511 keV
Range: N/A
Decay Daughters: Zn68 (Stable)
Status: FDA Approvals: NETSPOT® (2016), LOCAMETZ® (2022), ILLUCIX® (2021)
Target(s):
- FAP
Ligand Class: Small Molecules
Chelator: DOTA
Eligibility
Inclusion
- patients with gastrointestinal tumors: diagnosed by pathological needle biopsy
Exclusion
- refuse or cannot endure surgery pregnant women
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