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Clinical Trial · NCT06726161
Study of the Theranostic Pair RYZ811 (Diagnostic) and RYZ801 (Therapeutic) to Identify and Treat Subjects With GPC3+ (Glypican-3) Unresectable HCC
Overview
Phase 1/2 randomized, controlled, open-label trial of theranostic pair RYZ811 (diagnostic) and RYZ801 (therapeutic) to identify and treat subjects with GPC3+ unresectable hepatocellular carcinoma (HCC)
Sponsor
RayzeBio, Inc.
Phase
Phase 1/2
Contacts
Freddy Escorcia, MD, PhD (STUDY_DIRECTOR)
RayzeBio Clinical Trials (CONTACT)
clinicaltrials@rayzebio.com
1-619-657-0057
ClinicalTrials.gov
NCT06726161Drug / Compound
RYZ801
Isotope(s):
ACTINIUM-225
Radioisotope: Ac-225
Theranostic Role: Therapeutic Agent & SPECT Imaging
T1/2 (Half-Life): 9.9 Days
Decay Mode: ALPHA, GAMMA
Energy: 5.8-8.4 MeV
Range: 47-85 micrometers
Decay Daughters: Ra225, Fr221, At217, Bi213, 209, Po213, 209, TL209, 205
Status: Clinical Trials Only
Target(s):
- GPC3
Eligibility
Inclusion
- Histologically/cytologically confirmed diagnosis of HCC.
Exclusion
- Previously treated central nervous system (CNS) metastasis without recovery from acute side effects
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