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Clinical Trial · NCT06991738
Phase 1/2, Open-Label Study of the Safety, Dosimetry and Efficacy of a 3-Dose Regimen of Escalating Doses of 177Lu-DOTA-EB-TATE in Adult Patients With Metastatic, Radioactive Iodine Non-Responsive Oncocytic (Hurthle-Cell) Thyroid Cancer
Overview
Oncocytic (Hurthle cell) thyroid cancer (HTC) is a rare disease with few treatment options. Researchers are developing a radioactive drug that targets a protein that appears in high numbers on HTC cancer cells. Objective: To test a radioactive drug (177LuDOTA-EB-TATE) in people with HTC.
Sponsor
National Institute of Diabetes and Digestive and Kidney Diseases
Phase
Phase 1/2
Contacts
Joanna Klubo-Gwiezdzinska, M.D.
joanna.klubo-gwiezdzinska@nih.gov
(301) 496-5052
Padmasree Veeraraghavan, R.N.
padmasree.veeraraghavan@nih.gov
(301) 451-7710
ClinicalTrials.gov
NCT06991738Drug / Compound
Lu 177-DOTA-EB-TATE
Isotope(s):
LUTETIUM-177
Radioisotope: Lu-177
Theranostic Role: Therapeutic Agent & SPECT Imaging
T1/2 (Half-Life): 6.7 Days
Decay Mode: BETA, GAMMA
Energy: Eβeta max 497 keV, Gamma 113-208 keV
Range: In Tissue: 0.25-2mm
Decay Daughters: Hf177
Status: FDA Approvals: PLUVICTO® (2022), LUTATHERA® (2017)
Target(s):
- SSTR+
Ligand Class: Small Molecules
Chelator: DOTA
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