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Clinical Trial · NCT02945826
uPAR-PET/MRI in Glioblastoma Multiforme
Overview
The purpose of this study is to investigate the applicability of urokinase plasminogen activator receptor (uPAR) Positron Emission Tomography (PET) / MRI molecular imaging of glioblastoma.
Phase
Phase 2
Contacts
Dorthe Skovgaard, Md, PhD (PRINCIPAL_INVESTIGATOR)
Dorthe Skovgaard, MD, PhD (CONTACT)
dskovgaard@dadlnet.dk
+4561274706
Kjaer Andreas, professor (CONTACT)
akjaer@sund.ku.dk
+4535454011
ClinicalTrials.gov
NCT02945826Drug / Compound
AE105
Isotope(s):
GALLIUM-68
Radioisotope: Ga-68
Theranostic Role: PET Imaging
T1/2 (Half-Life): 68 minutes
Decay Mode: POSITRON β+ (88.9%), GAMMA, ELECTRON CAPTURE (8.7%)
Energy: Beta: max 1.9 MeV Gamma 1.1 MeV, 511 keV
Range: N/A
Decay Daughters: Zn68 (Stable)
Status: FDA Approvals: NETSPOT® (2016), LOCAMETZ® (2022), ILLUCIX® (2021)
Target(s):
- uPAR
Ligand Class: Peptides
Chelator: NOTA
Eligibility
Inclusion
- Patients where imaging with MRI or CT is suspicious of having glioblastoma multiforme, and patients, and who is referred for stereotactic biopsy, chemotherapy or surgery
- The participants must be capable of understanding and giving full informed written consent
Exclusion
- Lactation/breast feeding
- Known allergy towards 68Ga-NOTA-AE105
- Pregnancy
- Weight above 140 kg
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