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Clinical Trial · NCT02020720
18F-DOPA-PET in Planning Surgery in Patients With Gliomas
Overview
This pilot clinical trial studies fluorine F 18 fluorodopa (18F-DOPA)-positron emission tomography (PET) in planning surgery in patients with gliomas. New imaging procedures, such as 18F-DOPA-PET scan, may help find gliomas and may help in planning surgery.
Sponsor
Mayo Clinic
Phase
Early Phase 1
Contacts
Debra H. Brinkmann, Ph.D. (PRINCIPAL_INVESTIGATOR)
Nadia N. Laack, M.D. (PRINCIPAL_INVESTIGATOR)
ClinicalTrials.gov
NCT02020720Drug / Compound
DOPA
Isotope(s):
FLUORINE-18
Radioisotope: F-18
Theranostic Role: PET Imaging
T1/2 (Half-Life): 1.8 Hours
Decay Mode: POSITRON β+ (96.7%), ELECTRON CAPTURE (3.3%), GAMMA 511 keV
Energy: Eβ+ 635 keV
Range: N/A
Decay Daughters: O18 (Stable)
Status: FDA Approvals: FDG (Cancer 2005): GLUDEF®, METATRACE® AXUMIN® (2016), PYLARIFY® (2023), POSLUMA® (2024)
Target(s):
- Amino Acid Transport
Ligand Class: Small Molecules
Eligibility
Inclusion
- Ability to provide tissue for mandatory correlative research component
- Planned craniotomy and resection or biopsy
- MRI findings compatible with newly diagnosed or recurrent high- or low-grade malignant glioma
Exclusion
Exclusion criteria not yet provided.
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