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Clinical Trial · NCT06439914
First-in-human Study of Interferon-y PET Imaging to Assess Response to Immunotherapy
Overview
The goal of this clinical trial is to investigate the use of \[89Zr\]Zr-DFO-emapalumab as an IFN-γ PET imaging agent to detect lesions and response to therapy among treatment-naïve non-small cell lung cancer (NSCLC) patients. PET scans following the imaging agent will be completed prior to and about 30 days after starting immunotherapy.
Sponsor
Barbara Ann Karmanos Cancer Institute
Phase
Phase 1
Contacts
Nerissa T Viola, PhD (PRINCIPAL_INVESTIGATOR)
Nerissa T Viola, PhD (CONTACT)
violan@karmanos.org
3135768309
ClinicalTrials.gov
NCT06439914Drug / Compound
DFO-emapalumab
Isotope(s):
ZIRCONIUM-89
Radioisotope: Zr89
Theranostic Role: PET Imaging
T1/2 (Half-Life): 78 Hours
Decay Mode: POSITRON β+ (22%), ELECTRON CAPTURE (76%), GAMMA
Energy: max 0.9 MeV, E mean 397 keV, Gamma 511 keV
Range: N/A
Decay Daughters: Y89 (Stable)
Status: Clinical Trials Only
Target(s):
- IFN-γ
Ligand Class: Antibodies
Chelator: DFO
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