Clinical Trial · NCT01832116

89Zr-MMOT PET Imaging in Pancreatic and Ovarian Cancer Patients

Overview

The purpose of this multicenter imaging sub study is to evaluate the biodistribution and organ pharmacokinetics of 89Zr-MMOT0530A in patients with unresectable pancreatic or platinum-resistant ovarian cancer. MMOT0530A is a monoclonal antibody that targets an antigen overexpressed in pancreatic and ovarian cancer. Subsequent to imaging with 89Zr-MMOT0530A, patients will be treated with DMOT4039A in the DMO4993g protocol (clinicaltrials.gov identifier NCT01469793) after this study. DMOT4039A is an antibody-drug conjugate composed of the monoclonal antibody MMOT0530A and the mitotic agent monomethyl auristatin (MMAE). By imaging patients with the monoclonal antibody MMOT0530A before treatment, the correlation between tumor uptake of 89Zr-MMOT0530A and response to DMOT4039A therapy will be assessed.

Sponsor

University Medical Center Groningen

Phase

Phase 1

Contacts

Henk M Verheul, MD PhD (PRINCIPAL_INVESTIGATOR)

Elisabeth G. de Vries, MD PhD (PRINCIPAL_INVESTIGATOR)

ClinicalTrials.gov

NCT01832116

Eligibility

Inclusion

Adequate hematological, renal and liver function
Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1
Measureable disease, defined as at least one bi-dimensionally measurable non-lymph node lesion \>/= 1 cm in long-axis diameter on spiral CT scan or at least one bi-dimensionally measurable lymph node measuring \>/= 1.5 cm in short-axis diameter on spiral CT scan
Histologically documented, incurable, locally advanced or metastatic disease for which no standard therapy exists, consisting of one of the following: Unresectable pancreatic ductal adenocarcinoma or platinum-resistant ovarian cancer

Exclusion

Known active infection
Pregnant or breastfeeding women
Current Grade \>/= 2 toxicity (except for alopecia, anorexia and fatigue) from prior therapy or Grade \>/= 2 neuropathy
Untreated or active cerebral nervous system (CNS) metastases
Treatment with anti-tumor therapy, including chemotherapy, biologic, experimental or hormonal therapy, within 4 weeks prior to Day 1