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Clinical Trial · NCT03319641
PSMA-PET Imaging for Advanced ACC/SDC
Overview
Diagnostic study which evaluates the level of PSMA expression in patients with locally advanced, recurrent and/or metastatic ACC/SDC of ≥18 years old with 68Ga-PSMA-PET/CT imaging in order to establish whether these patients are eligible for 177Lu-PSMA therapy
Sponsor
Radboud University Medical Center
Phase
N/A
Contacts
Carla ML van Herpen, MD, PhD (PRINCIPAL_INVESTIGATOR)
ClinicalTrials.gov
NCT03319641Drug / Compound
PSMA-11
Isotope(s):
GALLIUM-68
Radioisotope: Ga-68
Theranostic Role: PET Imaging
T1/2 (Half-Life): 68 minutes
Decay Mode: POSITRON β+ (88.9%), GAMMA, ELECTRON CAPTURE (8.7%)
Energy: Beta: max 1.9 MeV Gamma 1.1 MeV, 511 keV
Range: N/A
Decay Daughters: Zn68 (Stable)
Status: FDA Approvals: NETSPOT® (2016), LOCAMETZ® (2022), ILLUCIX® (2021)
Target(s):
- PSMA
Ligand Class: Small Molecules
Chelator: HBED-CC
Eligibility
Inclusion
- locally advanced, recurrent or metastatic ACC/SDC
Exclusion
- Breast feeding
- Pregnancy
- Impaired liver function: AST and ALT ≥ 2.5 x ULN (≥5 x ULN for patients with liver metastases)
- Severe claustrophobia
- Impaired renal function: MDRD \<30 ml/min/1,73 m2
- Contra-indication for PET imaging
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