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Clinical Trial · NCT05321316
Nectin-4 Specific LMW PET Probe Imaging in Urothelial Carcinoma
Overview
To evaluate the ability of \[68Ga\]N188 to detect nectin-4 overexpression in patients with urothelial carcinoma, especially in patients with recurrent or advanced bladder cancer.
Sponsor
Peking University Cancer Hospital & Institute
Phase
N/A
Contacts
Zhi Yang, Professor (CONTACT)
pekyz@163.com
010-88196495
Hua Zhu, Professor (CONTACT)
zhuhuabch@pku.edu.cn
010-88196495
ClinicalTrials.gov
NCT05321316Drug / Compound
N188
Isotope(s):
GALLIUM-68
Radioisotope: Ga-68
Theranostic Role: PET Imaging
T1/2 (Half-Life): 68 minutes
Decay Mode: POSITRON β+ (88.9%), GAMMA, ELECTRON CAPTURE (8.7%)
Energy: Beta: max 1.9 MeV Gamma 1.1 MeV, 511 keV
Range: N/A
Decay Daughters: Zn68 (Stable)
Status: FDA Approvals: NETSPOT® (2016), LOCAMETZ® (2022), ILLUCIX® (2021)
Target(s):
- Nectin-4
Ligand Class: Small Molecules
FDG
Isotope(s):
FLUORINE-18
Radioisotope: F-18
Theranostic Role: PET Imaging
T1/2 (Half-Life): 1.8 Hours
Decay Mode: POSITRON β+ (96.7%), ELECTRON CAPTURE (3.3%), GAMMA 511 keV
Energy: Eβ+ 635 keV
Range: N/A
Decay Daughters: O18 (Stable)
Status: FDA Approvals: FDG (Cancer 2005): GLUDEF®, METATRACE® AXUMIN® (2016), PYLARIFY® (2023), POSLUMA® (2024)
Target(s):
- Glucose Transport
Ligand Class: Small Molecules
Eligibility
Inclusion
- Good follow-up compliance;
- Heart function is normal;
- Normal heart function;
- 1. 18-75 years old, male or female;
- Estimated survival ≥12 weeks;
Exclusion
- Pregnant patients;
- 1. Serious abnormality of liver, kidney and blood;
- Pregnant and lactation women;3\) unable to lie flat for half an hour; 4) Refuse to join the clinical investigator; 5) Suffering from claustrophobia or other mental diseases; 6) Other conditions that researchers deem unsuitable for participating in the experiment.
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