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Clinical Trial · NCT02437539
Evaluation of a New Radiotracer (68Ga-NOTA-AE105) for Diagnosing Aggressive Cancer With Positron Emission Tomography
Overview
The primary objective of the study is to test a new radiotracer called 68Ga-NOTA-AE105 for PET imaging of uPAR (urokinase plasminogen activator receptor). The tracer has the potential of identifying the invasive cancer phenotype, thereby distinguishing between aggressive and less aggressive tumors. This is a first in human study to test the radiotracer in cancer patients. The biodistribution and tumor uptake will be evaluated by repeated PET imaging (10 minutes, 1 hour and 2 hours post injection).
Phase
Phase 1
Contacts
Dorthe Skovgaard, MD, PhD (PRINCIPAL_INVESTIGATOR)
ClinicalTrials.gov
NCT02437539Drug / Compound
NOTA-AE105
Isotope(s):
GALLIUM-68
Radioisotope: Ga-68
Theranostic Role: PET Imaging
T1/2 (Half-Life): 68 minutes
Decay Mode: POSITRON β+ (88.9%), GAMMA, ELECTRON CAPTURE (8.7%)
Energy: Beta: max 1.9 MeV Gamma 1.1 MeV, 511 keV
Range: N/A
Decay Daughters: Zn68 (Stable)
Status: FDA Approvals: NETSPOT® (2016), LOCAMETZ® (2022), ILLUCIX® (2021)
Target(s):
- uPAR
Ligand Class: Peptides
Chelator: NOTA
Eligibility
Inclusion
- diagnosed with cancer of prostate, breast or urinary bladder
Exclusion
- pregnancy
- claustrophobia
- contraindication for the use of intravenous CT contrast-agencies
- lactation
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