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Clinical Trial · NCT07724535
18F-grazy-02 PET/CT of Granzyme B Expression for Monitoring Immunotherapy
Overview
This is an open-label PET/CT study to investigate the safety and clinical monitoring value of 18F-grazy-02 in patients with lymphoma or solid tumors receiving immunotherapy, including immune checkpoint inhibition and CAR-T cell therapy.
Sponsor
Peking University Cancer Hospital & Institute
Phase
Phase 1/2
Contacts
Linyu Zhang (CONTACT)
zhanglinyu1@pku.edu.cn
+86010-82805175
ClinicalTrials.gov
NCT07724535Drug / Compound
grazy-02
Isotope(s):
FLUORINE-18
Radioisotope: F-18
Theranostic Role: PET Imaging
T1/2 (Half-Life): 1.8 Hours
Decay Mode: POSITRON β+ (96.7%), ELECTRON CAPTURE (3.3%), GAMMA 511 keV
Energy: Eβ+ 635 keV
Range: N/A
Decay Daughters: O18 (Stable)
Status: FDA Approvals: FDG (Cancer 2005): GLUDEF®, METATRACE® AXUMIN® (2016), PYLARIFY® (2023), POSLUMA® (2024)
Target(s):
- Granzyme B
Ligand Class: Peptides
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