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Clinical Trial · NCT06688305
68Ga-NI-FAPI PET/CT: First-in-human Study in Patients With Various Cancers
Overview
68Ga-NI-FAPI is a novel radiotracer incorporating a hypoxia sensitive nitroimidazole (NI)-moiety and a FAP-targeting. In this study, we observed the safety, biodistribution, radiation dosimetry and diagnostic value of 68Ga-NI-FAPI PET/CT in patients with different types of cancer.
Sponsor
First Affiliated Hospital of Fujian Medical University
Phase
Early Phase 1
Contacts
Weibing Miao, MD
miaoweibing@126.com
+86-0591-87981618
Jie Zang, MD
15901495106@163.com
+86-0591-87981619
ClinicalTrials.gov
NCT06688305Drug / Compound
68Ga-NI-FAPI
Isotope(s):
GALLIUM-68
Radioisotope: Ga-68
Theranostic Role: PET Imaging
T1/2 (Half-Life): 68 minutes
Decay Mode: POSITRON β+ (88.9%), GAMMA, ELECTRON CAPTURE (8.7%)
Energy: Beta: max 1.9 MeV Gamma 1.1 MeV, 511 keV
Range: N/A
Decay Daughters: Zn68 (Stable)
Status: FDA Approvals: NETSPOT® (2016), LOCAMETZ® (2022), ILLUCIX® (2021)
Target(s):
- FAP
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