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Clinical Trial · NCT05828238
Positron Emission Tomograph(PET) Imaging Explores the Role of SF-DEVD-2 in Monitoring Tumor Efficacy
Overview
This is a single arm study to determining the value of apoptotic molecular probe SF-DEVD-2 in the early evaluation of tumor efficacy and comparing it head-to-head wihe 18F-FDG(18F-2-fluoro-2-deoxy-D-glucose)
Phase
Early Phase 1
Contacts
Chunjing Yu (CONTACT)
ycj_wxd1978@163.com
15312238622
Chunjing Yu (PRINCIPAL_INVESTIGATOR)
ClinicalTrials.gov
NCT05828238Drug / Compound
SF-DEVD-2
Isotope(s):
FLUORINE-18
Radioisotope: F-18
Theranostic Role: PET Imaging
T1/2 (Half-Life): 1.8 Hours
Decay Mode: POSITRON β+ (96.7%), ELECTRON CAPTURE (3.3%), GAMMA 511 keV
Energy: Eβ+ 635 keV
Range: N/A
Decay Daughters: O18 (Stable)
Status: FDA Approvals: FDG (Cancer 2005): GLUDEF®, METATRACE® AXUMIN® (2016), PYLARIFY® (2023), POSLUMA® (2024)
Target(s):
- Caspase-3
Ligand Class: Small Molecules
FDG
Isotope(s):
FLUORINE-18
Radioisotope: F-18
Theranostic Role: PET Imaging
T1/2 (Half-Life): 1.8 Hours
Decay Mode: POSITRON β+ (96.7%), ELECTRON CAPTURE (3.3%), GAMMA 511 keV
Energy: Eβ+ 635 keV
Range: N/A
Decay Daughters: O18 (Stable)
Status: FDA Approvals: FDG (Cancer 2005): GLUDEF®, METATRACE® AXUMIN® (2016), PYLARIFY® (2023), POSLUMA® (2024)
Target(s):
- Glucose Transport
Ligand Class: Small Molecules
Eligibility
Inclusion
- Age18-70, male or female;
- Pathology is HER3+、triple negative patients
- Diagnosed with stage 2 or 3 breast cancer
- Solid tumors、masses larger than 2cm with lymph node metastasis
- 1. Patients voluntarily signed informed consent;
Exclusion
- Abnormal liver and kidney function (more than five times the normal value)
- Diagnosis level of breast cancer stage 4 or second time tumor patients
- 1. Age greater than or equal to 70 years old
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