Clinical Trial · NCT03756077

A Study of the Value of Hybrid PET/MR and PET/CT in Prostate Cancer

Overview

According to the latest data from the China National Cancer Center, prostate cancer has become the most common tumor in the urinary system since 2008. However, conventional imaging techniques including transrectal ultrasound , computed tomography and bone scintigraphy are not sensitive or specific. About 40% of resectable lesions cannot be detected by these techniques. Positron Emission Tomography (PET) provides a valuable tool for the diagnosis and staging of prostate cancer. Recently, prostate-specific membrane antigen (PSMA) as a new novel positron tracer has shown to be effective to detect primary lesions, recurrent and metastatic lesions of prostate cancer. In this prospective study, the investigators will use the most advanced imaging equipments, integrated PET/MR, and PET/CT with prostate cancer-specific imaging agent 68Ga-PSMA and conventional imaging agent \[F-18\]fluorodeoxyglucose to image patients with or suspected of prostate cancer, the aim is to explore the value of hybrid PET/MR and PET/CT in prostate cancer.

Sponsor

Norwegian University of Science and Technology

Contacts

Xiaoli Lan, MD, PhD (PRINCIPAL_INVESTIGATOR)

Xiaoli Lan, MD, PhD (CONTACT)

lxl730724@hotmail.com

+86-13886193262

ClinicalTrials.gov

NCT03756077

Drug / Compound

PSMA-11

Isotope(s):
Target(s):
  • PSMA
Ligand Class: Small Molecules
Chelator: HBED-CC
Linker: Ahx

FDG

Isotope(s):
Target(s):
  • Glucose Transport
Ligand Class: Small Molecules

Eligibility

Inclusion

  • Patients suspected of or diagnosed with prostate cancer

Exclusion

  • Acute systemic diseases and electrolyte disorders
  • Patients with known malignancy in other organs
  • Other serious comorbidities evaluated by primary investigator
  • Patients with severe claustrophobia or unstable vital sigh