Clinical Trial · NCT03573011

PSMA PET/CT for Prostate Cancer

Overview

Prostate cancer is the most frequently occurring male cancer in Belgium. Patients who have been treated for prostate cancer, i.e. by surgery and/or radiotherapy, in a substantial degree suffer from a tumor recurrence, often diagnosed by an increase in serum tumor marker Prostate Specific Antigen (PSA) within the first few years. In these patients with evidence of a tumor recurrence after primary treatment, it is important to most exactly define the location(s) of tumor, to guide appropriate therapy by surgery, radiotherapy and/or hormonotherapy. In so-called oligo-metastatic disease targeted therapy may still be curative and prevent the disease from spreading to distant locations. Therefore it is of paramount importance to have an accurate tool of medical imaging to localize all possible locations to be treated.

Phase

Phase 2

Contacts

Piet Ost, Prof. (PRINCIPAL_INVESTIGATOR)

ClinicalTrials.gov

NCT03573011

Eligibility

Inclusion

  • Patients diagnosed with prostate cancer, either in the setting of diagnosis of biochemical recurrence after previous treatment, or at primary diagnosis and staging.

Exclusion

  • Patients with heart failure if ejection fraction \< 45% (phase 2 trial)
  • Physically or mentally unfit to perform the sequential procedures
  • History of anaphylactic shock after administration of Visipaque CT contrast (phase 2 trial)
  • Refusal of patient to be informed about accidental findings on scans