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Clinical Trial · NCT03448458
Gallium Ga 68-DOTATATE PET/CT in Diagnosing Patients With Metastatic Castration Resistant Prostate Cancer
Overview
This pilot clinical trial studies how well gallium Ga 68-DOTATATE positron emission tomography (PET)/computed tomography (CT) works in treating patients with castration resistant prostate cancer that has spread to other placed in the body. Gallium Ga 68-DOTATATE PET/CT may help doctors to identify those patients with early neuroendocrine transdifferentiation and who are at greater risk for poor outcomes.
Sponsor
Emory University
Phase
Phase 2
Contacts
Mehmet Asim Bilen, MD (PRINCIPAL_INVESTIGATOR)
ClinicalTrials.gov
NCT03448458Drug / Compound
DOTATATE
Isotope(s):
GALLIUM-68
Radioisotope: Ga-68
Theranostic Role: PET Imaging
T1/2 (Half-Life): 68 minutes
Decay Mode: POSITRON β+ (88.9%), GAMMA, ELECTRON CAPTURE (8.7%)
Energy: Beta: max 1.9 MeV Gamma 1.1 MeV, 511 keV
Range: N/A
Decay Daughters: Zn68 (Stable)
Status: FDA Approvals: NETSPOT® (2016), LOCAMETZ® (2022), ILLUCIX® (2021)
Target(s):
- SSTR2
Ligand Class: Peptides
Chelator: DOTA
Eligibility
Inclusion
- Patients with metastatic castration resistant prostate carcinoma with skeletal, visceral and/or nodal involvement
- Ability to lie still for PET scanning
Exclusion
- Inability to lie still for PET scanning
- Patients without metastatic castration resistant prostate carcinoma with skeletal, visceral and/or nodal involvement
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