Clinical Trial · NCT05236387

Evaluating the Ability of 99mTc-Tilmanocept to Identify Clipped Nodes in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy and Sentinel Lymph Node Dissection

Overview

The purpose of the present study is to evaluate the ability of 99mTc-TM to identify the clipped node after neoadjuvant chemotherapy (NAC) and to compare this percentage with historical national data. This study will also evaluate pain and discomfort after injection and pathological features of clipped nodes and any additional nodes removed.

Sponsor

Johns Hopkins University

Contacts

Mehran Habibi, MD (PRINCIPAL_INVESTIGATOR)

ClinicalTrials.gov

NCT05236387

Eligibility

Inclusion

  • The patient has been diagnosed with invasive Stage 2-3 breast cancer (T1-3; N1-2).
  • The patient has no history of inflammatory breast cancer.
  • The patient has no matted node on examination (N3).
  • The patient is a candidate for surgical intervention, with sentinel lymph node assessment being a part of the surgical plan.
  • The patient is eligible for neoadjuvant chemotherapy (NAC).

Exclusion

  • The patient has clinical and/or radiological evidence of metastatic or systemic disease. Oligo metastatic disease is acceptable (one organ and controlled).