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Clinical Trial · NCT01302821
C11 AMT Positron Emission Tomography (PET) Imaging in Patients With Metastatic Invasive Breast Cancer
Overview
The purpose of this research project is to create images of where and how the amino acid (the building blocks of proteins)Tryptophan is processed in normal and abnormal tissue in the patient's body. Tryptophan is a normal building block of proteins in the body. Sometimes in the case of cancer and other diseases, Tryptophan is processed abnormally, and possible treatments for this abnormality are of great interest because of the potential to improve cancer care.
Sponsor
H. Lee Moffitt Cancer Center and Research Institute
Phase
N/A
Contacts
Hatem Soliman, M.D. (PRINCIPAL_INVESTIGATOR)
ClinicalTrials.gov
NCT01302821Drug / Compound
AMT
Isotope(s):
CARBON-11
Radioisotope: C-11
Theranostic Role: PET Imaging, SPECT Imaging
T1/2 (Half-Life): 20.4 Min
Decay Mode: POSITRON β+ (99.8%), ELECTRON CAPTURE (0.2%), GAMMA
Energy: max 0.96 MeV, mean 386 keV, Gamma 511 keV
Range: N/A
Decay Daughters: B11 (Stable)
Status: FDA Approval: Carbon 11 Choline (2012)
Target(s):
- Amino Acid Transport
Ligand Class: Small Molecules
Eligibility
Inclusion
- Patients must be enrolled on the NCI 8461/MCC 16025 study.
- Consent for participation in this companion imaging study and be able to successfully complete a minimum of two AMT PET/CT scans.
Exclusion
- Not have any medical conditions prohibiting the successful completion of a minimum of two AMT PET/CT scans.
- Patients must not meet any of the exclusion criteria for the NCI 8461/ MCC 16025 study.
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