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Clinical Trial · NCT06852638
CD70-targeted immunoPET Imaging of Malignant Cancers
Overview
This study aims to determine the value of cluster of differentiation (CD70)-targeted immuno-positron emission tomography/computed tomography (immunoPET/CT) imaging for diagnosing human malignancies, including renal cell carcinoma (particularly clear cell renal cell carcinoma), lymphoma, and nasopharyngeal carcinoma (NPC), among others.
Sponsor
RenJi Hospital
Phase
Phase 2
Contacts
Jianjun Liu, Ph.D. & M.D. (STUDY_CHAIR)
Weijun Wei, Ph.D. & M.D. (PRINCIPAL_INVESTIGATOR)
Weijun Wei, Ph.D. & M.D. (CONTACT)
wwei@shsmu.edu.cn
15000083153
ClinicalTrials.gov
NCT06852638Drug / Compound
RD06
Isotope(s):
GALLIUM-68
Radioisotope: Ga-68
Theranostic Role: PET Imaging
T1/2 (Half-Life): 68 minutes
Decay Mode: POSITRON β+ (88.9%), GAMMA, ELECTRON CAPTURE (8.7%)
Energy: Beta: max 1.9 MeV Gamma 1.1 MeV, 511 keV
Range: N/A
Decay Daughters: Zn68 (Stable)
Status: FDA Approvals: NETSPOT® (2016), LOCAMETZ® (2022), ILLUCIX® (2021)
Target(s):
- CD70
Ligand Class: Small Proteins and Antibody Fragments
Chelator: NOTA
RESCA-RD06
Isotope(s):
FLUORINE-18
Radioisotope: F-18
Theranostic Role: PET Imaging
T1/2 (Half-Life): 1.8 Hours
Decay Mode: POSITRON β+ (96.7%), ELECTRON CAPTURE (3.3%), GAMMA 511 keV
Energy: Eβ+ 635 keV
Range: N/A
Decay Daughters: O18 (Stable)
Status: FDA Approvals: FDG (Cancer 2005): GLUDEF®, METATRACE® AXUMIN® (2016), PYLARIFY® (2023), POSLUMA® (2024)
Target(s):
- CD70
Ligand Class: Small Proteins and Antibody Fragments
Chelator: RESCA
Eligibility
Inclusion
- Histologically confirmed diagnosis of renal cancer (especially ccRCC)/lymphoma/NPC or suspected renal cancer/lymphoma/NPC by diagnostic imaging;
Exclusion
- Severe hepatic and renal insufficiency;
- Pregnancy；
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