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Clinical Trial · NCT02843542
Localization of Parathyroid Adenoma by Fluorocholine PET/MRI (Positron Emission Tomography -MRI)
Overview
A comparative prospective study to evaluate different imaging modalities (pet-ct and pet-mr) prior to surgery in parathyroid tumor patients.
Sponsor
Samsung Medical Center
Phase
N/A
Contacts
Avi hefetz, MD (PRINCIPAL_INVESTIGATOR)
Avi Hefetz, MD (CONTACT)
avihef1@gmail.com
972528661361
ClinicalTrials.gov
NCT02843542Drug / Compound
MIBI
Isotope(s):
TECHNETIUM-99m
Radioisotope: Tc-99m
Theranostic Role: SPECT Imaging
T1/2 (Half-Life): 6 Hours
Decay Mode: GAMMA
Energy: 140 keV (89.1%)
Range: N/A
Decay Daughters: Tc99
Status: FDA Approval: First in 1980’s
Target(s):
- Mitochondria-Targeting Moieties
Ligand Class: Small Molecules
choline
Isotope(s):
FLUORINE-18
Radioisotope: F-18
Theranostic Role: PET Imaging
T1/2 (Half-Life): 1.8 Hours
Decay Mode: POSITRON β+ (96.7%), ELECTRON CAPTURE (3.3%), GAMMA 511 keV
Energy: Eβ+ 635 keV
Range: N/A
Decay Daughters: O18 (Stable)
Status: FDA Approvals: FDG (Cancer 2005): GLUDEF®, METATRACE® AXUMIN® (2016), PYLARIFY® (2023), POSLUMA® (2024)
Target(s):
- Phospholipid Metabolism
Ligand Class: Small Molecules
Eligibility
Inclusion
- Symptomatic patients (constipation, depression, peptic ulcer, pathologic fractures, chronic fatigue, pain from a urinary tract stones etc..)or at least one of the following criteria:
- Urine Creatinine above 400 mg in 24 hours
- Blood calcium levels above 1 more than normal
- Patients who meet the criteria accepted in the World Health Organization (WHO) analysis:
Exclusion
- Patients with hyperthyroidism secondary and tertiary (secondary to kidney disease)
- Patients with sensitivity (allergy) technetium or 18FCH
- Pregnant women
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