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Clinical Trial · NCT03335280
68Ga-citrate PET/MR Imaging for Glioma
Overview
This is a prospective, single center, open-label study in adult patients with presumed World Health Organization (WHO) grade 3 or 4 glioma who will be undergoing surgical resection as standard of care. In some cases, patients will have had biopsy. Study participants will undergo 68Ga-citrate Positron Emission Tomography / magnetic resonance (PET/MR) prior to surgery.
Sponsor
University of California, San Francisco
Contacts
Susan Chang, MD (PRINCIPAL_INVESTIGATOR)
ClinicalTrials.gov
NCT03335280Drug / Compound
citrate
Isotope(s):
GALLIUM-68
Radioisotope: Ga-68
Theranostic Role: PET Imaging
T1/2 (Half-Life): 68 minutes
Decay Mode: POSITRON β+ (88.9%), GAMMA, ELECTRON CAPTURE (8.7%)
Energy: Beta: max 1.9 MeV Gamma 1.1 MeV, 511 keV
Range: N/A
Decay Daughters: Zn68 (Stable)
Status: FDA Approvals: NETSPOT® (2016), LOCAMETZ® (2022), ILLUCIX® (2021)
Target(s):
- Fe(II)
Ligand Class: Small Molecules
Chelator: citrate
Eligibility
Inclusion
- Karnofsky performance status of \>= 60
- World Health Organization (WHO) grade 3 or 4 glioma planning to undergo surgery
Exclusion
- Contraindications to magnetic resonance (MR) imaging (e.g. pacemakers, metallic implants, etc.)
- Contraindications to Positron Emission Tomography (PET) imaging (e.g. pregnant or breast-feeding woman)
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