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Clinical Trial · NCT02167204
18F-FLT PET/CT in Measuring Cell Proliferation in Patients With Brain Tumors
Overview
This pilot clinical trial studies fluorine F 18 fluorothymidine (FLT) positron emission tomography (PET)/computed tomography (CT) in measuring cell proliferation in patients with brain tumors. Comparing results of diagnostic procedures done before, during, and after treatment may help doctors measure tumor growth and plan the best treatment.
Sponsor
University of Washington
Phase
N/A
Contacts
Jason Rockhill (PRINCIPAL_INVESTIGATOR)
ClinicalTrials.gov
NCT02167204Drug / Compound
FLT
Isotope(s):
FLUORINE-18
Radioisotope: F-18
Theranostic Role: PET Imaging
T1/2 (Half-Life): 1.8 Hours
Decay Mode: POSITRON β+ (96.7%), ELECTRON CAPTURE (3.3%), GAMMA 511 keV
Energy: Eβ+ 635 keV
Range: N/A
Decay Daughters: O18 (Stable)
Status: FDA Approvals: FDG (Cancer 2005): GLUDEF®, METATRACE® AXUMIN® (2016), PYLARIFY® (2023), POSLUMA® (2024)
Target(s):
- cytosolic thymidine kinase 1
Ligand Class: Small Molecules
Eligibility
Inclusion
- Planned for treatment with radiation, chemotherapy and surgical resection or any of these treatment strategies combined
- Have a diagnosis or suspected diagnoses of brain tumor (primary, recurrent, or metastatic) by standard clinical diagnosis such as pathology or imaging
Exclusion
- Pregnancy
- Weight over 350 lbs.
- Inability to lie still for the imaging study
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