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Clinical Trial · NCT02037945
18F-Fluorocholine (18F-FCho) to Distinguish Necrosis From Recurrence in Brain Metastases
Overview
The main purpose of this study is to determine the distribution of 18F Fluorocholine (18F-FCH) in the brain which can help distinguishing radiation-induced scarring from tumor regrowth. In addition, the study will measure levels of 18F-FCH in the blood and (if applicable) in the brain lesion tissue that is removed as part of the planned brain surgery.
Sponsor
Memorial Sloan Kettering Cancer Center
Phase
N/A
Contacts
Kathryn Beal, MD (PRINCIPAL_INVESTIGATOR)
ClinicalTrials.gov
NCT02037945Drug / Compound
Fluorocholine
Isotope(s):
FLUORINE-18
Radioisotope: F-18
Theranostic Role: PET Imaging
T1/2 (Half-Life): 1.8 Hours
Decay Mode: POSITRON β+ (96.7%), ELECTRON CAPTURE (3.3%), GAMMA 511 keV
Energy: Eβ+ 635 keV
Range: N/A
Decay Daughters: O18 (Stable)
Status: FDA Approvals: FDG (Cancer 2005): GLUDEF®, METATRACE® AXUMIN® (2016), PYLARIFY® (2023), POSLUMA® (2024)
Target(s):
- Phospholipid Metabolism
Ligand Class: Small Molecules
Eligibility
Inclusion
- Evolving brain lesions post SRS requiring neurosurgical resection (whether for symptomatic control or to establish pathology)
Exclusion
Exclusion criteria not yet provided.
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