TheranosticTrials.org

Clinical Trial · NCT07023640

Application of the CD73-Targeted Probe ⁶⁸Ga-DOTA-mPNE PET/CT Imaging in the Diagnosis of Malignant Tumors

Overview

This study aims to perform ⁶⁸Ga-DOTA-mPNE PET/CT imaging in patients with clinically suspected or confirmed malignant tumors, in order to evaluate tracer uptake in lesions and analyze CD73 expression levels. In a subgroup of up to 10 participants, dynamic PET/CT imaging will be conducted for up to 90 minutes post-injection to assess the tracer's biodistribution and pharmacokinetic properties.Correlation analyses with relevant clinical indicators (such as pathology, immunohistochemistry, and molecular markers) will be carried out to further assess the diagnostic performance and clinical value of ⁶⁸Ga-DOTA-mPNE PET/CT in guiding tumor diagnosis and treatment. This study is expected to provide a novel molecular imaging tool for malignancies and offer clear, intuitive PET/CT-based evidence to support clinical diagnosis, differential diagnosis, and therapeutic decision-making.

Sponsor

Peking Union Medical College Hospital

Phase

N/A

Contacts

Xianzhong Zhang, PhD (PRINCIPAL_INVESTIGATOR)

Chenhao Jia, M.D. (CONTACT)

jiachenhao24@163.com

18548703382

ClinicalTrials.gov

NCT07023640

Drug / Compound

mPNE

Isotope(s):
Target(s):
  • CD73
Ligand Class: Small Molecules
Chelator: DOTA

Eligibility

Inclusion

  • No prior radiotherapy or chemotherapy; eligible for surgery or biopsy to obtain pathological diagnosis.
  • At least one measurable target lesion according to RECIST version 1.1 (Response Evaluation Criteria in Solid Tumors).

Exclusion

  • Unable to lie flat for 30 minutes.
  • Any other condition deemed unsuitable for study participation by the investigator.
  • Severe hepatic or renal dysfunction.
  • Women who are planning to conceive, currently pregnant, breastfeeding, or intend to have children during the study period are not eligible. Fertile participants must use effective contraception during the study.
  • Claustrophobia or other psychiatric disorders.
  • Refusal to participate in this clinical study.