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Clinical Trial · NCT04109729
This is an open label, prospective, trial that begins with a phase Ib safety run-in followed by a phase II expansion cohort.
Overview
Phase IB Study of Nivolumab in Combination With Radium-223 in Men With Metastatic Castration Resistant Prostate Cancer. This is an open label, prospective, trial that begins with a phase Ib safety run-in followed by a phase II expansion cohort.
Drug / Compound
Isotope(s):
RADIUM-223
Radioisotope: Ra-223
Theranostic Role: Therapeutic Agent
T1/2 (Half-Life): 11.4 Days
Decay Mode: ALPHA, BETA, GAMMA
Energy: Alpha (95%) 5-7.5 MeV Beta (3.6%) 445-492 keV Gamma (1%) 82-402 keV
Range: In Tissue <100 micrometers
Decay Daughters: 4 alpha daughters: Rn219, Po211,215, Bi211
Status: FDA Approval: XOFIGO® (2013)
Target(s):
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