XCancer

Study to Evaluate CD8 PET Imaging as a Marker of Immune Response to Stereotactic Body Radiation Therapy (ELIXR)

Description:

"This phase I trial investigates the effect of radiation therapy on the immune system, specifically CD8 positive (+) T cells, in lymphoma patients receiving bridging radiation therapy before CAR T-cell infusion, and metastatic patients with solid tumor malignancies receiving SBRT. CD8+ T cells are mainly found in lymph tissue and play a significant role in anti-tumor immunity. These cells can infiltrate tumor cells and kill them. Radiation therapy may recruit CD8 T cells and this recruitment may help with tumor control. Diagnostic procedures, such as zirconium Zr 89-Df-crefmirlimab positron emission tomography (PET), may be a less invasive way to check and monitor for CD8+ T cells before and after radiation therapy."

Sponsor:

City of Hope Medical Center

Phase:

Phase 1

Contacts:

Savita V Dandapani (PRINCIPAL_INVESTIGATOR)

Government Study Link:

NCT05371132 - Click here to see study on

ClinicalTrials.gov

Df-Crefmirlimab

Isotope(s):
Target(s):
  • CD8 Cells
Ligand Class: Small Proteins and Antibody Fragments
Chelator: DFO
Inclusion
  • Eastern Cooperative Oncology Group (ECOG) =\< 2
  • Metastatic patients of any solid tumor malignancy amenable for SBRT as determined by the radiation oncologist
  • Age: \>= 18 years
  • * Documented informed consent of the participant and/or legally authorized representative
  • Participant is willing and able to comply with all protocol required procedures
Exclusion
  • * Patient who have splenic disorders or had splenectomy that per PI would interfere with CD8 imaging
  • History of allergic reactions attributed to compounds of similar chemical or biologic composition to CD8 PET tracer
  • Serious nonmalignant disease or conditions that could compromise protocol objectives, in the opinion of the investigator
  • Females only: Pregnant or breastfeeding
  • Patients should not have any uncontrolled illness including ongoing or active infection