XCancer

A Pilot Study Using 18F-DOPA PET-guided Radiotherapy in Gliomas

Description:

For most brain tumors, radiation treatment is guided by a Magnetic Resonance Imaging (MRI) scan. In this study, information from a special scan, called a Positron Emission Tomography/ Computed Tomography (PET/CT) scan using an amino acid called Fluorine-18-L-dihydroxyphenylalanine (18F-DOPA) will also be used. This type of scan has shown promise in being able to better distinguish tumor from normal brain tissue and may help to more accurately plan radiation treatment. This type of scan can also assist the radiation oncologist in identifying the most aggressive regions of the tumor. The goal of this study is to compare the 18F-DOPA PET/CT scan with the MRI scan for identifying where the disease is that needs to be treated with radiation.

Sponsor:

Mayo Clinic

Contacts:

Nadia N Laack, MD (PRINCIPAL_INVESTIGATOR)

Debra Brinkmann, PhD (PRINCIPAL_INVESTIGATOR)

Deanna Pafundi, PhD (PRINCIPAL_INVESTIGATOR)

Government Study Link:

NCT02104310 - Click here to see study on

ClinicalTrials.gov

DOPA

Isotope(s):
Target(s):
  • Amino Acid Transport
Ligand Class: Small Molecules
Inclusion
  • CT simulation, 18F-DOPA PET imaging, and standard of care pre-radiotherapy MRI scans to be performed at Mayo Clinic Rochester.
Exclusion
  • Patients previously treated with radiation therapy.