XCancer

PET-CT Predicting Lymph Nodes Metastasis

Description:

This study is a single-center prospective clinical study that aims to evaluate the predictive value of preoperative 18F-FDG-PET-CT and 18F-FAPI-PET/CT for lymph node metastasis in patients with non-small cell lung cancer. The final pathological results were used to assess the predictive value of PET-CT for lymph node metastasis.

Sponsor:

Fudan University

Government Study Link:

NCT05970913 - Click here to see study on

ClinicalTrials.gov

FAPI

Isotope(s):
Target(s):
  • FAP
Ligand Class: Small Molecules

FDG

Isotope(s):
Target(s):
  • Glucose Transport
Ligand Class: Small Molecules
Inclusion
  • No history of malignant tumors.
  • No prior radiotherapy or chemotherapy for initial treatment.
  • Solitary tumor, or multiple tumors with only ground-glass nodules (GGNs) apart from the primary lesion.
  • Pathological confirmation of non-small cell lung cancer (NSCLC) either before or during surgery.
  • Diameter of the primary lesion ≤5cm, with a CTR between 0.5 and 1.
Exclusion
  • History of malignant tumors.
  • Received neoadjuvant therapy.
  • Pleural dissemination observed during surgery.
  • Locally advanced or distant metastasis.
  • Histopathological examination reveals lung malignancies other than non-small cell lung cancer (NSCLC).