XCancer

Comparison of [68Ga]Ga-CTR-FAPI and 18F-FDG PET/MRI for Lymph Node Staging in Rectal Cancer

Description:

This is a prospective, single-center, diagnostic study designed to compare the accuracy of \[68Ga\]Ga-CTR-FAPI PET/MRI and \[18\]F-FDG PET/MRI for the detection of lymph node metastasis in patients with initially untreated, resectable middle to high rectal cancer. The study aims to evaluate whether \[68Ga\]Ga-CTR-FAPI PET/MRI provides higher sensitivity and specificity than traditional 18F-FDG PET/MRI at both the patient level and the lymph node level.

Sponsor:

Peking University Cancer Hospital & Institute

Phase:

N/A

Contacts:

Minghe Zhao (CONTACT)

dzhao3163@gmail.com

0086-15600896700

Government Study Link:

NCT07552207 - Click here to see study on

ClinicalTrials.gov

FDG

Isotope(s):
Target(s):
  • Glucose Transport
Ligand Class: Small Molecules

CTR-FAPI

Isotope(s):
Target(s):
  • FAP
Ligand Class: Small Molecules
Inclusion
  • Confirmed rectal adenocarcinoma by pathological biopsy.
  • Lower margin of the tumor is ≥ 5 cm and ≤15 cm from the anal verge.
  • Planned to undergo radical surgery.
Exclusion
  • History of pelvic radiotherapy or chemotherapy.