XCancer

PET With [18F]HX4 in Head and Neck Cancer

Description:

The aim of this study is to (i) Determine if tumor hypoxia can be accurately visualised with \[18F\] HX4 PET imaging in head and neck tumors (ii) correlate the \[18F\] HX4 PET images with blood and tissue markers and (iii) investigate the quality and optimal timing of \[18F\] HX4 PET imaging (iv) compare \[18F\] HX4 PET uptake with \[18F\] FDG PET uptake before and after treatment.

Sponsor:

Unknown Organization

Phase:

N/A

Contacts:

Philppe Lambin, Prof. Dr. (PRINCIPAL_INVESTIGATOR)

Government Study Link:

NCT01347281 - Click here to see study on

ClinicalTrials.gov

HX4

Isotope(s):
Target(s):
  • Hypoxia
Ligand Class: Small Molecules

FDG

Isotope(s):
Target(s):
  • Glucose Transport
Ligand Class: Small Molecules
Inclusion
  • No previous surgery to the head and neck
  • Scheduled for primary curative (concurrent chemo-) radiotherapy
  • * Histological or cytological confirmed HNSSC of the oral cavity, oropharynx, hypopharynx, larynx, T2-T3-T4, any N, M0
  • Tumor diameter ≥ 2,5 cm
  • WHO performance status 0 to 2
Exclusion
  • * No recent (\< 3 months) myocardial infarction
  • Not pregnant or breast feeding and willing to take adequate contraceptive measures during the study
  • No Uncontrolled infectious disease