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PET Biodistribution Study of 68Ga-FAPI-46 in Patients With Different Malignancies: An Exploratory Biodistribution Study With Histopathology Validation
Description:
This exploratory study investigates how an imaging technique called 68Ga-FAPi-46 PET/CT can determine where and to which degree the FAPI tracer (68Ga-FAPi-46) accumulates in normal and cancer tissues in patients with cancer. Because some cancers take up 68Ga-FAPi-46 it can be seen with PET. FAP stands for Fibroblast Activation Protein. FAP is produced by cells that surround tumors (cancer associated fibroblasts). The function of FAP is not well understood but imaging studies have shown that FAP can be detected with FAPI PET/CT. Imaging FAP with FAPI PET/CT may in the future provide additional information about various cancers.
Sponsor:
Jonsson Comprehensive Cancer Center (UCLA)
Contacts:
Stephanie Lira (Clinical Trials Program Manager)stephanielira@mednet.ucla.edu
(310) 206-7372
Hamzah Alam (Clinical Research Coordinator)halam@mednet.ucla.edu
3102067372
Maria Contreras (Clinical Research Coordinator)mmcontreras@mednet.ucla.edu
3108257336
Government Study Link:
NCT04459273 - Click here to see study onClinicalTrials.gov
68Ga-FAPi-46
- FAP
- Patients are ≥ 18 years old at the time of the radiotracer administration.
- Patients who are scheduled to undergo surgical resection or tissue biopsy of the primary tumor and/or metastasis
- Patient can provide written informed consent
- Patient is able to remain still for duration of imaging procedure (up to one hour)
- Patient is pregnant or nursing
- Patients with any new cancer therapy between the baseline PET/CT and the investigational FAPI PET/CT
- Patient has underlying disease which might interfere with the collection of high quality data
Patient Education
Patient Education Not Yet Provided
Publications
Publications Not Yet Provided
Locations
Not yet provided. Contact Stephanie Lira for more information.
(310) 206-7372
stephanielira@mednet.ucla.edu
