XCancer

CAIX-targeted PET/CT in Solid Tumors

Description:

Tumor hypoxic microenvironment plays an important role in the initiation and progression of solid tumors, as well as tumor invasion, metastasis, and treatment resistance. Carbonic anhydrase IX (CAIX), as a crucial downstream molecule regulated by hypoxia-inducible factor-1 (HIF-1), is highly expressed in various solid tumors and is closely associated with tumor invasiveness, treatment response, and prognosis; thus, it represents an ideal target for tumor diagnosis and therapy. This study aims to explore the diagnostic value of CAIX-targeted PET/CT imaging in various solid tumors, as well as the correlation between tumor uptake and tissue CAIX expression.

Sponsor:

Zhongnan Hospital

Phase:

N/A

Contacts:

Chongjiao Li, MD, PhD (CONTACT)

lcj0301@163.com

+86-27-67812698

Yong He, MD, PhD (PRINCIPAL_INVESTIGATOR)

Government Study Link:

NCT07833085 - Click here to see study on

ClinicalTrials.gov

Inclusion
  • Participants with suspected malignant solid tumors or patients with newly diagnosed or recurrent/metastatic malignant solid tumors confirmed by histopathology;
  • The ECOG PS score for physical condition in the Eastern Cancer Collaboration Group is 0-1 points;
Exclusion
  • Pregnant or lactating women;
  • Participants with severe obesity, claustrophobia, or other reasons who are unable to undergo PET scans;
  • Other situations that researchers believe should be excluded and documented.
  • Participants with severe liver and kidney dysfunction and cardiac dysfunction;